USP7 anticorps

N° du produit ABIN129596

Détail du produit anti-USP7 anticorps

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of human HAUSP protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 130 kDa in size corresponding to HAUSP protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.98 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: HAUSP (USP7 Produits)

Synonymes: anticorps CG1490, anticorps Dmel\\CG1490, anticorps USP7, anticorps 2210010O09Rik, anticorps AA409944, anticorps AA617399, anticorps AU019296, anticorps AW548146, anticorps C80752, anticorps Hausp, anticorps HAUSP, anticorps TEF1, anticorps UBP, anticorps Ubiquitin-specific protease 7, anticorps ubiquitin carboxyl-terminal hydrolase 7, anticorps ubiquitin specific peptidase 7, anticorps Usp7, anticorps LOC100201254, anticorps USP7

Sujet: HAUSP (also known as deubiquitinating enzyme 7, herpes virus associated ubiquitin specific protease, TEF1, ubiquitin carboxyl terminal hydrolase 7, ubiquitin specific protease 7, ubiquitin thiolesterase 7, and USP7) is a novel p53 interacting protein. HAUSP was identified by mass spectrometry of affinity purified p53 associated factors by Li et al. HAUSP strongly stabilizes p53, even in the presence of excess MDM2, and also induces p53-dependent cell growth repression and apoptosis. HAUSP has an intrinsic enzymatic activity that specifically de-ubiquitinates p53 both in vivo and in vitro. Expression of a catalytically inactive point mutation of HAUSP in cells increased the levels of p53 ubiquitination and also destabilized p53. Li et al concluded that their findings revealed an important mechanism by which p53 can be stabilized by direct de-ubiquitination and also implied that HAUSP may function as a tumor suppressor in vivo through the stabilization of p53.
Synonyms: Deubiquitinating enzyme 7 antibody, herpes virus associated antibody, Herpes virus associated ubiquitin specific protease antibody, TEF 1 antibody, tef-1 antibody, TEF1 antibody, Ubiquitin carboxyl terminal hydrolase 7 antibody

ID gène: 7874, 150378533

UniProt: Q93009