PTENP1 anticorps (pSer29, pThr32)

N° du produit ABIN129639

N° du produit (Fournisseur): 600-401-859

Détail du produit anti-PTENP1 anticorps

Antigène: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Épitope: pSer29, pThr32

Reactivité: Humain, Chimpanzé, Chien, Macaque, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTENP1 est non-conjugé

Application: Western Blotting (WB), ELISA

N° du produit (Fournisseur): 600-401-859

Fournisseur: Rockland

Fonction: PTEN-P1 phospho S29/T32 Antibody

Réactivité croisée (Details): This affinity-purified antibody is directed against the phosphorylated form of human PTEN protein at the pS29 and pT32 residues.

Attributs du produit: Synonyms: rabbit anti-PTEN-P1 pS29 pT32 antibody, Phosphatase and tensin homolog 2, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Stérilité: Sterile filtered

Immunogène:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 223-237 of human PTEN protein.

Immunogen Type: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application:

Application Note: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 41 kDa in size corresponding to PTEN-P1 protein by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1:500 - 1:2,000

ELISA Dilution: 1:20,000 - 1:80,000

Other: User Optimized

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.87 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur PTENP1

Antigène: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Autre désignation: PTEN-P1 (PTENP1 Produits)

Sujet: Background: This gene (PTENP1) is a highly homologous pseudogene of PTEN.  PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

ID gène: 5728, 73765544

UniProt: O43460