HDAC1 anticorps (AA 466-482)
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- Antigène Voir toutes HDAC1 Anticorps
- HDAC1 (Histone Deacetylase 1 (HDAC1))
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Épitope
- AA 466-482
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HDAC1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Concentration Definition: by UV absorbance at 280 nm
- Immunogène
- Anti-HDAC-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1.
- Isotype
- IgG
- Top Product
- Discover our top product HDAC1 Anticorps primaire
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- Indications d'application
- Anti-HDAC-1 Antibody has been tested for use in ELISA, immunohistochemistry and western blot. Specific conditions for reactivity should be optimized by the end user. Specific nuclear staining is observed by IHC. Expect bands at 65 kDa in size corresponding to HDAC-1 by western blotting in the appropriate cell lysate or extract.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.33 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs." dans: Nature communications, Vol. 9, Issue 1, pp. 1698, (2018) (PubMed).
: "Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma." dans: British journal of cancer, Vol. 108, Issue 8, pp. 1648-58, (2013) (PubMed).
: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." dans: Oncogene, Vol. 23, Issue 46, pp. 7601-10, (2004) (PubMed).
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Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs." dans: Nature communications, Vol. 9, Issue 1, pp. 1698, (2018) (PubMed).
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- Antigène
- HDAC1 (Histone Deacetylase 1 (HDAC1))
- Autre désignation
- HDAC-1 (HDAC1 Produits)
- Sujet
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HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms: GON 10 antibody, HD 1 antibody, hdac1: histone deacetylase 1 antibody, Histone deacetylase 1 (HD1) antibody, Histone deacetylase 1 antibody, RPD3 (reduced potassium dependency yeast homolog) like 1 antibody - ID gène
- 3065, 13128860
- UniProt
- Q13547
- Pathways
- Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis
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