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CCDC98 anticorps (AA 1-313)

FAM175A Reactivité: Humain WB, IP, FACS Hôte: Souris Monoclonal ABRA1-01 unconjugated
N° du produit ABIN1302443
  • Antigène Voir toutes CCDC98 (FAM175A) Anticorps
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Épitope
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    AA 1-313
    Reactivité
    • 24
    • 19
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 37
    • 3
    Souris
    Clonalité
    • 37
    • 3
    Monoclonal
    Conjugué
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCDC98 est non-conjugé
    Application
    • 31
    • 13
    • 13
    • 12
    • 11
    • 9
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
    Réactivité croisée (Details)
    Human, Other not tested
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
    Clone
    ABRA1-01
    Isotype
    IgG
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-2 μg/mL. Intracellular staining.
    Western blotting: Reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Antigène
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Autre désignation
    ABRA1 (FAM175A Produits)
    Synonymes
    anticorps CCDC98, anticorps abra1, anticorps ccdc98, anticorps fam175a, anticorps ABRA1, anticorps 3830405G04Rik, anticorps 5630400M01Rik, anticorps AI506069, anticorps AL024423, anticorps AV118690, anticorps Ccdc98, anticorps RGD1305287, anticorps zgc:103522, anticorps abraxas 1, BRCA1 A complex subunit, anticorps Coiled-coil domain-containing protein 98, anticorps BRCA1 A complex subunit, anticorps family with sequence similarity 175 member A, anticorps abraxas 2a, BRISC complex subunit, anticorps abraxas 1, BRCA1 A complex subunit S homeolog, anticorps ABRAXAS1, anticorps abraxas1, anticorps Abraxas1, anticorps FAM175A, anticorps abraxas2a, anticorps abraxas1.S
    Sujet
    Abraxas 1, BRCA1 A complex subunit,ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.,ABRA1, Abraxas 1, CCDC98, FAM175A
    ID gène
    84142
    UniProt
    Q6UWZ7
    Pathways
    Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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