CD8 anticorps (PE,Cy5)

N° du produit ABIN133193

Détail du produit anti-CD8 anticorps (PE,Cy5)

Antigène: CD8

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est conjugé à/à la PE,Cy5

Application: Flow Cytometry (FACS)

Specificité: Rat CD8a

Purification: Ion exchange

Clone: OX-8

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/ml

Stock: 4 °C

Détails sur CD8

Antigène: CD8

Autre désignation: CD8 (CD8 Produits)

Synonymes: anticorps CD8, anticorps Leu2, anticorps MAL, anticorps p32, anticorps CD8a molecule, anticorps CD8A

Sujet: Anti-rat CD8a monoclonal antibody recognizes a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells, the majority of NK cells, and the granular intraepithelial leukocytes in the small intestine. (1,2,3,4.) The antigen recognized is a complex of surface glycoproteins of Mr 34,000, 39,000 and 76,000 Da and is the rat homologue of the human CD8 and the mouse Ly-2,3 antigen. (5,8) ABIN133193labels all peripheral T cells that are unlabelled by the ABIN000000 (W3/25) monoclonal antibody. It labels a T-cell subset which mediates the suppression of antibody formation (1) and the cytotoxic cell precursor. (2) ABIN133193and ABIN000000 can be used together to fractionate T cells by sorting in FACS or by rosette depletion (1,2) or can be used together to study subsets of T cells in the rat which mediate lethal graft vs. host disease. (7) This antibody is one of the 3 monoclonal antibodies which labels T lymphocyte populations in the rat, these being ABIN000000 (W3/13) which labels all T cells, as well as ABIN000000 (W3/25) and CL004TC(MRC 0X-8) which label non-overlapping T cell populations. These monoclonal antibodies used in concert are being employed extensively to investigate cellular aspects of the immune response in rats and prove to be useful as markers for functionally distinct subpopulations of lymphocytes.