BAX anticorps (AA 12-24)
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- Antigène Voir toutes BAX Anticorps
- BAX (BCL2-Associated X Protein (BAX))
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Épitope
- AA 12-24
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp BAX est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Mouse/Rat/Human/Monkey/Bovine Bax
- Attributs du produit
- Mouse Anti-Bax-UNLB
- Purification
- Purified
- Immunogène
- Bax peptide (a.a. 12-24) common to mouse, rat, and human
- Clone
- 6A7
- Isotype
- IgG1
- Top Product
- Discover our top product BAX Anticorps primaire
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- Indications d'application
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- Applications: WB - Quality tested , IP - Reported in literature , FC - Reported in literature , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , EM - Reported in literature , Neut - Reported in literature
- Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL
- Volume d'échantillon
- 1 mL
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C
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- Antigène
- BAX (BCL2-Associated X Protein (BAX))
- Autre désignation
- Bax (BAX Produits)
- Synonymes
- anticorps BAX-ALPHA, anticorps bax-A, anticorps xBax, anticorps xlbax, anticorps BAX, anticorps bax, anticorps fj16e01, anticorps wu:fc50b10, anticorps wu:fj16e01, anticorps BCL2L4, anticorps zgc:112983, anticorps BCL2 associated X, apoptosis regulator, anticorps BCL2-associated X protein L homeolog, anticorps BCL2-associated X protein, anticorps bcl2-associated X protein, a, anticorps bcl2-associated X protein, b, anticorps BAX, anticorps bax.L, anticorps bax, anticorps baxa, anticorps Bax, anticorps baxb
- Sujet
- Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program.
- Pathways
- Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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