CD28 anticorps

N° du produit ABIN135180

Détail du produit anti-CD28 anticorps

Antigène: CD28

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CD28 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Mouse CD28, Mr 40 kDa

Attributs du produit: Hamster Anti-Mouse CD28-UNLB

Purification: Purified

Immunogène: C57BL/6N mouse T cell lymphoma EL-4 cell line

Clone: 37-51

Isotype: IgG

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IP - Reported in literature , Costim - Reported in literature , Stim - Reported in literature , Activ - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

In vitro costimulation of T cells and NK cells

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-CD28 (ABIN135180)

Ershaid, Sharon, Doron, Raz, Shani, Cohen, Monteran, Leider-Trejo, Ben-Shmuel, Yassin, Gerlic, Ben-Baruch, Pasmanik-Chor, Apte, Erez: "NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis." dans: Nature communications, Vol. 10, Issue 1, pp. 4375, (2020) (PubMed).

Détails sur CD28

Antigène: CD28

Autre désignation: CD28 (CD28 Produits)

Synonymes: anticorps Tp44, anticorps CD28RNA, anticorps cd28, anticorps CD28 molecule, anticorps CD28 antigen, anticorps Cd28 molecule, anticorps CD28 molecule L homeolog, anticorps CD28, anticorps Cd28, anticorps cd28.L

Sujet: CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response