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CD130/gp130 anticorps

IL6ST Reactivité: Humain IHC, ELISA, FACS, Func Hôte: Souris Monoclonal B-R3 unconjugated
N° du produit ABIN1383678
  • Antigène Voir toutes CD130/gp130 (IL6ST) Anticorps
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Reactivité
    • 138
    • 62
    • 56
    • 19
    • 17
    • 17
    • 16
    • 4
    • 1
    • 1
    Humain
    Hôte
    • 114
    • 26
    • 4
    • 2
    • 1
    Souris
    Clonalité
    • 116
    • 31
    Monoclonal
    Conjugué
    • 51
    • 13
    • 9
    • 9
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD130/gp130 est non-conjugé
    Application
    • 98
    • 37
    • 35
    • 28
    • 28
    • 26
    • 16
    • 13
    • 10
    • 9
    • 9
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Functional Studies (Func)
    Specificité
    Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
    Purification
    Ion exchange chromatography
    Stérilité
    0.22 μm filtered
    Immunogène
    Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells
    Clone
    B-R3
    Isotype
    IgG2a, kappa
    Biological Activity Comment
    Inhibits IL-6, IL-11, CNTF, LIF and OSM activities
    Top Product
    Discover our top product IL6ST Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
    Agent conservateur
    Without preservative
    Stock
    4 °C
    Stockage commentaire
    Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
  • Chautard, Loubeau, Tchirkov, Chassagne, Vermot-Desroches, Morel, Verrelle: "Akt signaling pathway: a target for radiosensitizing human malignant glioma." dans: Neuro-oncology, Vol. 12, Issue 5, pp. 434-43, (2010) (PubMed).

    Waetzig, Chalaris, Rosenstiel, Suthaus, Holland, Karl, Vallés Uriarte, Till, Scheller, Grötzinger, Schreiber, Rose-John, Seegert: "N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130." dans: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1781-9, (2010) (PubMed).

    Memoli, Grandaliano, Soccio, Postiglione, Guida, Bisesti, Esposito, Procino, Marrone, Michael, Andreucci, Schena, Pertosa: "In vivo modulation of soluble \" IL-6 receptor synthesis and release in ESRD." dans: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 4, pp. 1099-107, (2005) (PubMed).

    Duplomb, Chaigne-Delalande, Vusio, Raher, Jacques, Godard, Blanchard: "Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II." dans: Endocrinology, Vol. 144, Issue 12, pp. 5381-9, (2003) (PubMed).

    Jover, Bort, Gómez-Lechón, Castell: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, (2002) (PubMed).

    Burger, Guenther, Bakker, Schmalzing, Bernand, Baum, Duerr, Hocke, Steininger, Gebhart, Gramatzki: "Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma." dans: The hematology journal : the official journal of the European Haematology Association / EHA, Vol. 2, Issue 1, pp. 42-53, (2002) (PubMed).

    Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." dans: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

    Aoki, Narazaki, Kishimoto, Tosato: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." dans: Blood, Vol. 98, Issue 10, pp. 3042-9, (2001) (PubMed).

    Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).

    Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." dans: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

    Müller-Newen, Küster, Wijdenes, Schaper, Heinrich: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." dans: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).

    Blanchard, Duplomb, Raher, Vusio, Hoflack, Jacques, Godard: "Mannose 6-Phosphate/Insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transduction." dans: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24685-93, (1999) (PubMed).

    Thiel, Behrmann, Dittrich, Muys, Tavernier, Wijdenes, Heinrich, Graeve: "Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway." dans: The Biochemical journal, Vol. 330 ( Pt 1), pp. 47-54, (1998) (PubMed).

    Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." dans: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).

    Auguste, Guillet, Fourcin, Olivier, Veziers, Pouplard-Barthelaix, Gascan: "Signaling of type II oncostatin M receptor." dans: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15760-4, (1997) (PubMed).

    Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." dans: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).

    Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." dans: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).

    Gu, Costes, Lu, Zhang, Pitard, Moreau, Bataille, Wijdenes, Rossi, Klein: "Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop." dans: Blood, Vol. 88, Issue 10, pp. 3972-86, (1996) (PubMed).

  • Antigène
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Autre désignation
    CD130 (IL6ST Produits)
    Synonymes
    anticorps CD130, anticorps CDW130, anticorps GP130, anticorps IL-6RB, anticorps 5133400A03Rik, anticorps AA389424, anticorps BB405851, anticorps D13Ertd699e, anticorps gp130, anticorps Ac1055, anticorps Gp130, anticorps Il-6rb, anticorps IL-6, anticorps interleukin 6 signal transducer, anticorps IL6ST, anticorps Il6st, anticorps il6st
    Sujet
    Gp130
    Poids moléculaire
    130-140 kDa
    Pathways
    Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
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