IL6
Reactivité: Rat
WB, IHC, IP, ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Buffer
Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
Agent conservateur
Without preservative
Stock
4 °C
Stockage commentaire
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Sprynski, Hose, Caillot, Réme, Shaughnessy, Barlogie, Seckinger, Moreaux, Hundemer, Jourdan, Meissner, Jauch, Mahtouk, Kassambara, Bertsch, Rossi, Goldschmidt, Klein: "The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor." dans: Blood, Vol. 113, Issue 19, pp. 4614-26, (2009) (PubMed).
Adam, Rabe, Suthaus, Grötzinger, Rose-John, Scheller: "Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor." dans: Journal of virology, Vol. 83, Issue 10, pp. 5117-26, (2009) (PubMed).
Moreau, Garban, Attal, Michallet, Marit, Hulin, Benboubker, Doyen, Mohty, Yakoub-Agha, Leyvraz, Casassus, Avet-Loiseau, Garderet, Mathiot, Harousseau: "Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma." dans: Blood, Vol. 112, Issue 9, pp. 3914-5, (2008) (PubMed).
Garban, Attal, Michallet, Hulin, Bourhis, Yakoub-Agha, Lamy, Marit, Maloisel, Berthou, Dib, Caillot, Deprijck, Ketterer, Harousseau, Sotto, Moreau: "Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma." dans: Blood, Vol. 107, Issue 9, pp. 3474-80, (2006) (PubMed).
Moreau, Hullin, Garban, Yakoub-Agha, Benboubker, Attal, Marit, Fuzibet, Doyen, Voillat, Berthou, Ketterer, Casassus, Monconduit, Michallet, Najman, Sotto, Bataille, Harousseau: "Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol." dans: Blood, Vol. 107, Issue 1, pp. 397-403, (2005) (PubMed).
Song, Torphy, Griswold, Shealy: "Coming of age: anti-cytokine therapies." dans: Molecular interventions, Vol. 2, Issue 1, pp. 36-46, (2004) (PubMed).
Moreaux, Legouffe, Jourdan, Quittet, Rème, Lugagne, Moine, Rossi, Klein, Tarte: "BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone." dans: Blood, Vol. 103, Issue 8, pp. 3148-57, (2004) (PubMed).
Derhaschnig, Bergmair, Marsik, Schlifke, Wijdenes, Jilma: "Effect of interleukin-6 blockade on tissue factor-induced coagulation in human endotoxemia." dans: Critical care medicine, Vol. 32, Issue 5, pp. 1136-40, (2004) (PubMed).
Smith, Barg, Weedon, Papengelis, Smeets, Tak, Kraan, Coleman, Ahern: "Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints." dans: Annals of the rheumatic diseases, Vol. 62, Issue 4, pp. 303-7, (2003) (PubMed).
Choy: "Interleukin 6 receptor as a target for the treatment of rheumatoid arthritis." dans: Annals of the rheumatic diseases, Vol. 62 Suppl 2, pp. ii68-9, (2003) (PubMed).
Derenne, Monia, Dean, Taylor, Rapp, Harousseau, Bataille, Amiot: "Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells." dans: Blood, Vol. 100, Issue 1, pp. 194-9, (2002) (PubMed).
Delneste, Charbonnier, Herbault, Magistrelli, Caron, Bonnefoy, Jeannin: "Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages." dans: Blood, Vol. 101, Issue 1, pp. 143-50, (2002) (PubMed).
Leblond, Dhedin, Mamzer Bruneel, Choquet, Hermine, Porcher, Nguyen Quoc, Davi, Charlotte, Dorent, Barrou, Vernant, Raphael, Levy: "Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders." dans: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 3, pp. 772-8, (2001) (PubMed).
Jego, Bataille, Pellat-Deceunynck: "Interleukin-6 is a growth factor for nonmalignant human plasmablasts." dans: Blood, Vol. 97, Issue 6, pp. 1817-22, (2001) (PubMed).
Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: "IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells." dans: Cancer research, Vol. 61, Issue 7, pp. 3096-104, (2001) (PubMed).
Haddad, Paczesny, Leblond, Seigneurin, Stern, Achkar, Bauwens, Delwail, Debray, Duvoux, Hubert, Hurault de Ligny, Wijdenes, Durandy, Fischer: "Treatment of B-lymphoproliferative disorder with a monoclonal anti-interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial." dans: Blood, Vol. 97, Issue 6, pp. 1590-7, (2001) (PubMed).
Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." dans: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).
Foussat, Wijdenes, Bouchet, Gaidano, Neipel, Balabanian, Galanaud, Couderc, Emilie: "Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes." dans: European cytokine network, Vol. 10, Issue 4, pp. 501-8, (2000) (PubMed).