MCPH1 anticorps (AA 11-110)

N° du produit ABIN1385183

Détail du produit anti-MCPH1 anticorps

Antigène: MCPH1 (Microcephalin 1 (MCPH1))

Épitope: AA 11-110

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCPH1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Souris

Homologie: Human,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MCPH1

Antigène: MCPH1 (Microcephalin 1 (MCPH1))

Autre désignation: Microcephalin 1/BRIT1 (MCPH1 Produits)

Synonymes: anticorps RGD1560642, anticorps MGC83773, anticorps MCPH1, anticorps mct, anticorps brit1, anticorps MGC148665, anticorps BRIT1, anticorps MCT, anticorps 5430437K10Rik, anticorps D030046N04Rik, anticorps microcephalin 1, anticorps microcephalin 1 S homeolog, anticorps microcephaly, primary autosomal recessive 1, anticorps Mcph1, anticorps mcph1.S, anticorps MCPH1, anticorps mcph1

Sujet:

Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

Pathways: Stem Cell Maintenance