C17orf75 anticorps (AA 210-260)

N° du produit ABIN1385449

Détail du produit anti-C17orf75 anticorps

Antigène: C17orf75 (Chromosome 17 Open Reading Frame 75 (C17orf75))

Épitope: AA 210-260

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C17orf75 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C17orf75

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur C17orf75

Antigène: C17orf75 (Chromosome 17 Open Reading Frame 75 (C17orf75))

Autre désignation: C17orf75 (C17orf75 Produits)

Synonymes: anticorps NJMU-R1, anticorps C17orf75, anticorps DKFZp469B234, anticorps chromosome 18 C17orf75 homolog, anticorps chromosome 17 open reading frame 75 L homeolog, anticorps chromosome 17 open reading frame, human C17orf75, anticorps chromosome 17 open reading frame 75, anticorps RIKEN cDNA 5730455P16 gene, anticorps C18H17orf75, anticorps c17orf75.L, anticorps C17H17orf75, anticorps C17orf75, anticorps 5730455P16Rik

Sujet:

Synonyms: Njmu R1, Protein kinase Njmu R1, Protein Njmu R1, NJMU_HUMAN.

Background: C17orf75 is a 396 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

ID gène: 64149

UniProt: Q9HAS0