TET2 anticorps (AA 1165-1215)

N° du produit ABIN1385661

Détail du produit anti-TET2 anticorps

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Épitope: AA 1165-1215

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TET2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TET2

Isotype: IgG

Information d'application

Indications d'application: IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TET2

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Autre désignation: TET2 (TET2 Produits)

Synonymes: anticorps KIAA1546, anticorps MDS, anticorps Ayu17-449, anticorps E130014J05Rik, anticorps mKIAA1546, anticorps RGD1311625, anticorps tet methylcytosine dioxygenase 2, anticorps TET2, anticorps Tet2

Sujet:

Synonyms: MDS, KIAA1546, Methylcytosine dioxygenase TET2, TET2, Nbla00191

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

ID gène: 54790

UniProt: Q6N021

Pathways: L'effet Warburg