HEY2 anticorps

N° du produit ABIN1385664

Détail du produit anti-HEY2 anticorps

Antigène: HEY2 (Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HEY2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HEY2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur HEY2

Antigène: HEY2 (Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2))

Autre désignation: HEY2 (HEY2 Produits)

Synonymes: anticorps CHF1, anticorps GRIDLOCK, anticorps GRL, anticorps HERP1, anticorps HESR2, anticorps HRT2, anticorps bHLHb32, anticorps Herp1, anticorps Hrt2, anticorps hesr2, anticorps grl, anticorps zgc:136746, anticorps hes related family bHLH transcription factor with YRPW motif 2, anticorps hairy/enhancer-of-split related with YRPW motif 2, anticorps hes-related family bHLH transcription factor with YRPW motif 2, anticorps HEY2, anticorps Hey2, anticorps hey2

Sujet:

Synonyms: bHLHb32, Cardiovascular helix loop helix factor 1, Cardiovascular helix-loop-helix factor 1, CHF1, Class B basic helix-loop-helix protein 32, GRIDLOCK, GRL, Hairy and enhancer of split related 2, Hairy and enhancer of split-related protein 2, Hairy related transcription factor 2, Hairy-related transcription factor 2, Hairy/enhancer-of-split related with YRPW mot protein 2, hCHF1, HERP, HERP1, HES related repressor protein 1, HES-related repressor protein 2, HESR-2, HESR2, HEY2, HEY2_HUMAN, hHRT2, HRT-2, HRT2, Protein gridlock homolog.

Background: The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate and establishing boundaries of gene expression. Notch signaling activates the Hairy/Enhancer of split (HES) genes, which encode basic helix-loop-helix (bHLH) transcriptional repressors that are critical for directing embryonic patterning and development. The Hairy-related transcription factors (HRTs) comprise a subclass of bHLH proteins that exhibit structural similarity with the HES proteins and include HRT1, HRT2 and HRT3. The HRT family (also designated Hesr, Hey, CHF and Gridlock) contain a bHLH domain, an Orange domain and a novel YRPW domain, which is absent in HRT3. The Hairy-related genes map to human chromosomes 8q21, 6q21 and 1p34.3 for HRT1, HRT2 and HRT3, respectively, and are downstream targets for Notch signaling. HRT1 is expressed in the somitic mesoderm, central nervous system, kidney, heart, nasal epithelium and limb buds in murine embryos as well as in adult tissues. It has altered expression in many breast, lung and kidney tumors. Like HRT1, HRT2 and HRT3 are also expressed in developing somites, heart and nervous system.

ID gène: 23493

Pathways: Regulation of Muscle Cell Differentiation