VISTA anticorps
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- Antigène Voir toutes VISTA Anticorps
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VISTA est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human SISP1/GI24
- Isotype
- IgG
- Top Product
- Discover our top product VISTA Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
- Autre désignation
- GI24 (VISTA Produits)
- Synonymes
- anticorps MGC112715, anticorps MGC151567, anticorps B7-H5, anticorps B7H5, anticorps GI24, anticorps PP2135, anticorps SISP1, anticorps Dies1, anticorps VISTA, anticorps V-set immunoregulatory receptor, anticorps vsir, anticorps Vsir, anticorps VSIR
- Sujet
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Synonyms: C10orf54, GI24_HUMAN, Platelet receptor Gi24, PP2135, SISP1, stress induced secreted protein 1, UNQ730/PRO1412.
Background: Platelet receptor GI24, also known as SISP1 or PP2135, is a 311 amino acid single-pass type I membrane protein that contains one Ig-like (immunoglobulin-like) domain. GI24 is thought to contribute to tumor-invasive growth in the collagen matrix and is encoded by a gene that maps to human chromosome 10q22.1. Chromosome 10 contains over 800 genes, 135 million nucleotides and comprises nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.
- Pathways
- Cancer Immune Checkpoints
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