EP400 anticorps (AA 1051-1250)

N° du produit ABIN1386134

Détail du produit anti-EP400 anticorps

Antigène: EP400 (E1A Binding Protein P400 (EP400))

Épitope: AA 1051-1250

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EP400 est non-conjugé

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human p400

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur EP400

Antigène: EP400 (E1A Binding Protein P400 (EP400))

Autre désignation: P400 (EP400 Produits)

Synonymes: anticorps CAGH32, anticorps P400, anticorps TNRC12, anticorps 1700020J09Rik, anticorps AU023439, anticorps mDomino, anticorps mKIAA1498, anticorps p400, anticorps E1A binding protein p400, anticorps EP400 N-terminal-like protein, anticorps helicase domino, anticorps E1a binding protein P400, anticorps EP400, anticorps Ep400, anticorps LOC738562, anticorps LOC5570719, anticorps CpipJ_CPIJ007689, anticorps CpipJ_CPIJ007688, anticorps CpipJ_CPIJ007686, anticorps CpipJ_CPIJ008061

Sujet:

Synonyms: CAG repeat protein 32, CAGH32, DKFZP434I225, Domino homolog, E1A binding protein p400, EP 400, EP400, FLJ42018, FLJ45115, hDomino, KIAA1498, KIAA1818, p400 kDa SWI2/SNF2 related protein, P400 SWI2/SNF2-related protein, TNRC12, Trinucleotide repeat containing 12, Trinucleotide repeat containing gene 12 protein, EP400_HUMAN.

Background: NuAR is a multi-protein histone acetyltransferase complex that functions to acetylate the nucleosomal Histones H4 and H2A, thereby activating transcription of select target genes. p400, also known as EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is a component of the NuAR complex. Expressed in brain, liver, thymus, lung, spleen, colon and kidney, p400 regulates the transcriptional activity of proteins such as MZF-1 and contributes to the ATPase and helicase activities of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A. The ability of p400 to regulate transcriptional and apoptotic activity suggests that the NuAR complex may be a crucial component of cell proliferation, transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due to alternative splicing events.

ID gène: 57634

Pathways: Chromatin Binding