SPPL2B anticorps (AA 55-135)

N° du produit ABIN1386177

Détail du produit anti-SPPL2B anticorps

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Épitope: AA 55-135

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPPL2B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SPPL2B

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SPPL2B

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Autre désignation: IMP4/SPPL2B (SPPL2B Produits)

Synonymes: anticorps SPPL2B, anticorps wu:fc16e01, anticorps wu:fc85d12, anticorps zgc:136525, anticorps MGC147524, anticorps IMP-4, anticorps IMP4, anticorps PSH4, anticorps PSL1, anticorps 3110056O03Rik, anticorps AW550292, anticorps RGD1308556, anticorps signal peptide peptidase-like 2, anticorps signal peptide peptidase like 2B, anticorps signal peptide peptidase like 2B S homeolog, anticorps signal peptide peptidase-like 2B, anticorps sppl2, anticorps sppl2b, anticorps sppl2b.S, anticorps SPPL2B, anticorps Sppl2b

Sujet:

Synonyms: IMP4, Signal peptide peptidase-like 2B, Intramembrane protease 4, Protein SPP-like 2B, SPPL2B, SPP2B_HUMAN.

Background: SPPL2b is a 592 amino acid multi-pass membrane protein that contains one protease associated domain and belongs to the GXGD family of aspartic proteases. Localized to the membrane of the Golgi apparatus and to lysosomes, endosomes and the plasma membrane, SPPL2b functions as an intramembrane protease that specifically cleaves the transmembrane domain of TNF? Once cleaved, TNF?releases its intracellular domain, thus triggering the immunity-related expression of cytokines (also known as interleukins) which are used in various pathways throughout the body. SPPL2b also interacts with and catalyzes the intramembrane proteolysis of ITM2B (integral membrane protein 2B), a protein that, when mutated, is associated with dementia. Four isoforms of SPPL2b exist due to alternative splicing events.