Glutathione Synthetase anticorps (AA 81-160)

N° du produit ABIN1386180

Détail du produit anti-Glutathione Synthetase anticorps

Antigène: Glutathione Synthetase (GSS)

Épitope: AA 81-160

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Synthetase est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Glutathione Syntase

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Glutathione Synthetase

Antigène: Glutathione Synthetase (GSS)

Autre désignation: GSS/Glutathione Synthetase (GSS Produits)

Synonymes: anticorps PRNP, anticorps 6835, anticorps CG32497, anticorps CG33065, anticorps CG6835, anticorps Dmel\\CG6835, anticorps F21A20.90, anticorps F21A20_90, anticorps GLUTATHIONE SYNTHETASE, anticorps GSHB, anticorps glutathione synthetase 2, anticorps GSHS, anticorps AI314904, anticorps GS-A/GS-B, anticorps gssls-a, anticorps glutathione synthetase, anticorps Glutathione Synthetase, anticorps glutathione synthetase 2, anticorps glutathione synthetase L homeolog, anticorps GSS, anticorps GSH2, anticorps Tola_1250, anticorps PC1_3711, anticorps Dd586_3633, anticorps Kvar_0701, anticorps Alvin_0197, anticorps Nhal_0215, anticorps BC1002_0254, anticorps Cseg_4017, anticorps Snov_3844, anticorps Aazo_1904, anticorps M301_2613, anticorps Bresu_0515, anticorps Isop_1460, anticorps Marme_4020, anticorps Thicy_0325, anticorps Sinme_3668, anticorps Mesop_0757, anticorps Gss, anticorps gss.L

Sujet:

Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.

Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.

Pathways: L'effet Warburg