AFG3L2 anticorps (AA 531-600)

N° du produit ABIN1386200

Détail du produit anti-AFG3L2 anticorps

Antigène: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Épitope: AA 531-600

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFG3L2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AFG3L2

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur AFG3L2

Antigène: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Autre désignation: SCA28/AFG3L2 (AFG3L2 Produits)

Synonymes: anticorps MGC147390, anticorps si:ch211-12e1.4, anticorps SCA28, anticorps SPAX5, anticorps 2310036I02Rik, anticorps AW260507, anticorps Emv66, anticorps par, anticorps AFG3 like matrix AAA peptidase subunit 2, anticorps AFG3-like protein 2, anticorps AFG3 ATPase family gene 3-like 2 (S. cerevisiae), anticorps AFG3-like AAA ATPase 2, anticorps AFG3-like AAA ATPase 2 L homeolog, anticorps AFG3L2, anticorps LOC578526, anticorps afg3l2, anticorps afg3l2.L, anticorps Afg3l2

Sujet:

Synonyms: AFG3 ATPase family gene 3, yeast like 2, AFG3 ATPase family gene 3 like 2 yeast, AFG3 ATPase family gene 3 like 2, AFG3 like protein 2, ATPase family gene 3 like 2, ATPase family gene 3 yeast, FLJ25993, Paraplegin like protein, SCA28, Spinocerebellar ataxia 28, AFG32_HUMAN .

Background: AFG3L2 is a multi-pass membrane metalloprotease that contains one AAA (ATPase associated with diverse cellular activities) domain, a zinc-dependent binding motif, an RNA-binding region and an ATP/GTP binding site. Localizing to the mitochondrial membrane, AFG3L2 is ubiquitously expressed with highest expression levels in skeletal muscle and heart. AFG3L2 shares 69 % similarity with the yeast Afg3 protein and 49 % similarity with Paraplegin, a protein of mitochondria that is thought to be involved in signal transduction and chaperone-like activities. In mitochondria, AFG3L2 forms a complex with Paraplegin that is believed to regulate essential protein quality control. Mutations in the gene encoding either one of these proteins can result in hereditary spastic paraplegia, a degenerative spinal cord disorder that is characterized by muscle spasms, stiffness in the legs and, in some cases, incontinence.

Pathways: Skeletal Muscle Fiber Development