EPH Receptor B1 anticorps (pTyr928)

N° du produit ABIN1386364

Détail du produit anti-EPH Receptor B1 anticorps

Antigène: EPH Receptor B1 (EPHB1)

Épitope: pTyr928

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human EphB1 around the phosphorylation site of Tyr928

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur EPH Receptor B1

Antigène: EPH Receptor B1 (EPHB1)

Autre désignation: Eph receptor B1 (EPHB1 Produits)

Synonymes: anticorps ELK, anticorps EPHT2, anticorps Hek6, anticorps NET, anticorps ephb1-a, anticorps xek, anticorps Xek, anticorps MGC89790, anticorps EPHB1, anticorps CEK6, anticorps EK6, anticorps 9330129L11, anticorps AW488255, anticorps C130099E04Rik, anticorps Cek6, anticorps ENSMUSG00000074119, anticorps Elk, anticorps Elkh, anticorps Net, anticorps Ephb2, anticorps Erk, anticorps elk, anticorps EPH receptor B1, anticorps EPH receptor B1 S homeolog, anticorps ephrin type-B receptor 1, anticorps Eph receptor B1, anticorps EPHB1, anticorps ephb1.S, anticorps ephb1, anticorps LOC100467687, anticorps Ephb1

Sujet:

Synonyms: ELK, NET, Hek6, EPHT2, Ephrin type-B receptor 1, EPH tyrosine kinase 2, EPH-like kinase 6, EK6, Neuronally-expressed EPH-related tyrosine kinase, Tyrosine-protein kinase receptor EPH-2, EPHB1

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

ID gène: 2047

UniProt: P54762

Pathways: Signalisation RTK