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MLC1 anticorps (AA 321-377)

Reactivité: Souris, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1386787
  • Antigène Tous les produits MLC1
    MLC1
    Épitope
    • 14
    • 14
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 321-377
    Reactivité
    • 23
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 37
    • 1
    Lapin
    Clonalité
    • 38
    Polyclonal
    Conjugué
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MLC1 est non-conjugé
    Application
    • 32
    • 19
    • 12
    • 12
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Dog,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MLC1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Gu, Feng, Yu, Yuan, Yin, Ding, Zhao, Xu, Xu, Che: "Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway." dans: Oncotarget, Vol. 8, Issue 61, pp. 104104-104112, (2017) (PubMed).

  • Antigène
    MLC1
    Abstract
    MLC1 Produits
    Synonymes
    anticorps LVM, anticorps MLC, anticorps VL, anticorps AW048630, anticorps BB074274, anticorps Kiaa0027-hp, anticorps WKL1, anticorps mKIAA0027, anticorps si:ch211-192n14.1, anticorps megalencephalic leukoencephalopathy with subcortical cysts 1, anticorps megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human), anticorps MLC1, anticorps Mlc1, anticorps mlc1
    Sujet

    Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

    Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

    ID gène
    23209
    UniProt
    Q15049
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