EGR2 anticorps (AA 351-450)

N° du produit ABIN1386818

Détail du produit anti-EGR2 anticorps

Antigène: EGR2 (Early Growth Response 2 (EGR2))

Épitope: AA 351-450

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGR2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EGR2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-EGR2 (ABIN1386818)

Balakrishnan, Stykel, Touahri, Stratton, Biernaskie, Schuurmans: "Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0153256, (2016) (PubMed).

Détails sur EGR2

Antigène: EGR2 (Early Growth Response 2 (EGR2))

Autre désignation: EGR2 (EGR2 Produits)

Synonymes: anticorps AT591, anticorps CMT1D, anticorps CMT4E, anticorps KROX20, anticorps Egr-2, anticorps Krox-20, anticorps Krox20, anticorps NGF1-B, anticorps Zfp-25, anticorps Zfp-6, anticorps KRX-20, anticorps cb427, anticorps egr2, anticorps id:ibd5073, anticorps krox20, anticorps krx20, anticorps wu:fb71h10, anticorps zgc:92210, anticorps frb35, anticorps early growth response 2, anticorps early growth response 2b, anticorps early growth response 2a, anticorps EGR2, anticorps Egr2, anticorps egr2b, anticorps egr2a

Sujet:

Synonyms: CMT1D, CMT4E, DKFZp686J1957, Early growth response 2, Early growth response protein 2, EGR-2, egr2, EGR2_HUMAN, FLJ14547, KROX 20 Drosophila homolog, Krox 20 homolog Drosophila, KROX20, Krox20 protein, Zinc finger protein Krox-20, AT591.

Background: Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92 % identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.

ID gène: 1959