ZNRF3 anticorps (AA 120-165)

N° du produit ABIN1386947

Détail du produit anti-ZNRF3 anticorps

Antigène: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Épitope: AA 120-165

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNRF3 est non-conjugé

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZNRF3

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ZNRF3

Antigène: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Autre désignation: ZNRF3 (ZNRF3 Produits)

Synonymes: anticorps BK747E2.3, anticorps RNF203, anticorps AA591877, anticorps BC019575, anticorps Gm1167, anticorps zinc and ring finger 3, anticorps Znrf3, anticorps ZNRF3

Sujet:

Synonyms: RNF203, BK747E2.3, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, ZNRF3, KIAA1133

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

ID gène: 84133

UniProt: Q9ULT6

Pathways: Signalisation WNT