FEZ1 anticorps

N° du produit ABIN1387129

Détail du produit anti-FEZ1 anticorps

Antigène: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FEZ1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FEZ1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FEZ1

Antigène: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Autre désignation: FEZ1 (FEZ1 Produits)

Synonymes: anticorps UNC-76, anticorps UNC76, anticorps wu:fj14c12, anticorps zgc:73258, anticorps fez1, anticorps xfez1, anticorps fasciculation and elongation protein zeta 1, anticorps fasciculation and elongation protein zeta 1 (zygin I), anticorps fasciculation and elongation protein zeta 1 L homeolog, anticorps FEZ1, anticorps Fez1, anticorps fez1, anticorps fez1.L

Sujet:

Synonyms: Fasciculation and elongation protein zeta 1, Fasciculation and elongation protein zeta-1, Fez 1, Fez, Fez-like zinc finger protein, FEZ1, FEZ1_HUMAN, Fezl, Forebrain embryonic zinc-finger like protein, Zpf312, Zygin 1, Zygin I, Zygin-1, Zygin1, ZyginI.

Background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

ID gène: 9638