FEZF1 anticorps (AA 199-280)

N° du produit ABIN1387262

Détail du produit anti-FEZF1 anticorps

Antigène: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Épitope: AA 199-280

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FEZF1 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZNF312B

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FEZF1

Antigène: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Autre désignation: ZNF312B/FEZF1 (FEZF1 Produits)

Synonymes: anticorps RGD1560480, anticorps fezf, anticorps znf312b, anticorps MGC145310, anticorps FEZ, anticorps ZNF312B, anticorps 3110069A13Rik, anticorps Fez, anticorps Zfp312-like, anticorps fez-like, anticorps fez, anticorps fezf2, anticorps wu:fc29c05, anticorps wu:fc89h05, anticorps zgc:153730, anticorps Fez family zinc finger 1, anticorps FEZ family zinc finger 1, anticorps Fez family zinc finger protein 1, anticorps FEZ family zinc finger 1 S homeolog, anticorps Fezf1, anticorps FEZF1, anticorps fezf1, anticorps Tsp_12536a, anticorps Tsp_12536, anticorps fezf1.S

Sujet:

Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.