INTS3 anticorps (AA 960-998)

N° du produit ABIN1387357

Détail du produit anti-INTS3 anticorps

Antigène: INTS3 (Integrator Complex Subunit 3 (INTS3))

Épitope: AA 960-998

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INTS3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human INTS3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur INTS3

Antigène: INTS3 (Integrator Complex Subunit 3 (INTS3))

Autre désignation: INTS3 (INTS3 Produits)

Synonymes: anticorps INTS3, anticorps Ints3, anticorps NV18802, anticorps ACYPI009450, anticorps DL3335W, anticorps FCAALL.260, anticorps embryo defective 2739, anticorps C1orf193, anticorps C1orf60, anticorps INT3, anticorps SOSS-A, anticorps C77668, anticorps RGD1304593, anticorps si:dkey-27c15.2, anticorps integrator complex subunit 3, anticorps integrator complex subunit 3 L homeolog, anticorps embryo defective 2739, anticorps INTS3, anticorps ints3.L, anticorps CpipJ_CPIJ008133, anticorps ints3, anticorps Ints3, anticorps LOC100168776, anticorps emb2739

Sujet:

Synonyms: INT3, SOSSA, SOSS-A, C1orf60, C1orf193, Integrator complex subunit 3, SOSS complex subunit A, Sensor of single-strand DNA complex subunit A, Sensor of ssDNA subunit A, INTS3

Background: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

ID gène: 65123

UniProt: Q68E01