UBE2N anticorps (AA 56-152)

N° du produit ABIN1387434

Détail du produit anti-UBE2N anticorps

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Épitope: AA 56-152

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2N est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Ube2N/UBC13

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur UBE2N

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Autre désignation: Ube2N (UBE2N Produits)

Synonymes: anticorps UBC13, anticorps UbcH-ben, anticorps UbcH13, anticorps 1500026J17Rik, anticorps AL022654, anticorps BB101821, anticorps ube2n, anticorps wu:fb11b03, anticorps wu:fc08b06, anticorps zgc:55726, anticorps ubc13, anticorps ubch-ben, anticorps UBE2N, anticorps ube2nl, anticorps zgc:63901, anticorps ubiquitin conjugating enzyme E2 N, anticorps ubiquitin-conjugating enzyme E2N, anticorps ubiquitin conjugating enzyme E2 N S homeolog, anticorps ubiquitin-conjugating enzyme E2Na, anticorps ubiquitin-conjugating enzyme E2Nb, anticorps UBE2N, anticorps Ube2n, anticorps ube2n.S, anticorps ube2na, anticorps LOC100533434, anticorps ube2n, anticorps ube2nb

Sujet:

Synonyms: UBC 13, UBC13, UbCH ben, Ube 2N, Ube2n, UBE2N_HUMAN, ubiquitin carrier protein N, Ubiquitin conjugating enzyme E2 N, Ubiquitin conjugating enzyme E2N homologous to yeast UBC13, Ubiquitin conjugating enzyme E2N UBC13 homolog yeast, Ubiquitin conjugating enzyme E2N, ubiquitin protein ligase N, Ubiquitin-conjugating enzyme E2 N, ubiquitin-conjugating enzyme E2N homologous to yeast UBC13, ubiquitin-conjugating enzyme E2N UBC13 homolog yeast, Ubiquitin-protein ligase N, Yeast UBC13 homolog, bendless like ubiquitin conjugating enzyme, Bendless-like ubiquitin-conjugating enzyme, BLU, EC 6.3.2.19, Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds, MGC131857, MGC8489.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBC13, also known as UBE2N or BLU, is a 152 amino acid member of the E2 ubiquitin-conjugating enzyme family. Existing as a heterodimer with Mms2 (also known as UBE2V2), UBC13 catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. Additionally, UBC13 mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage.

ID gène: 7334

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway