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HIP1 anticorps (AA 401-500)

HIP1 Reactivité: Humain WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1387494
  • Antigène Voir toutes HIP1 Anticorps
    HIP1 (Huntingtin Interacting Protein 1 (HIP1))
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivité
    • 29
    • 13
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 6
    Lapin
    Clonalité
    • 26
    • 3
    Polyclonal
    Conjugué
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HIP1 est non-conjugé
    Application
    • 22
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HIP1
    Isotype
    IgG
    Top Product
    Discover our top product HIP1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    HIP1 (Huntingtin Interacting Protein 1 (HIP1))
    Autre désignation
    HIP1 (HIP1 Produits)
    Synonymes
    anticorps HIP-I, anticorps ILWEQ, anticorps CG10971, anticorps Dmel\\CG10971, anticorps Hip1R, anticorps 2610109B09Rik, anticorps A930014B11Rik, anticorps E130315I21Rik, anticorps mKIAA4113, anticorps huntingtin interacting protein 1, anticorps Huntingtin interacting protein 1, anticorps HIP1, anticorps Hip1, anticorps hip1
    Sujet

    Synonyms: Huntingtin Interacting Protein HIP1, HIP I, HIP-1, HIP-I, hip1, HIP1/PDGFRB fusion gene, HIP1/PDGFRB fusion gene, included, HIP1_HUMAN, HIPI, Huntingtin interacting protein 1, Huntingtin-interacting protein 1, Huntingtin-interacting protein I, ILWEQ, KIAA4113, MGC126506, MGC27616, mKIAA4113.

    Background: Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product huntingtin. HIP1 (huntingtin-interacting protein 1), a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels, and exhibits nearly identical subcellular fractionation as huntingtin. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.

    Pathways
    Positive Regulation of Endopeptidase Activity
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