TNIP1 anticorps
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- Antigène Voir toutes TNIP1 Anticorps
- TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNIP1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human TNIP1
- Isotype
- IgG
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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A20-Binding Inhibitor of NF-κB 1 Ameliorates Neuroinflammation and Mediates Antineuroinflammatory Effect of Electroacupuncture in Cerebral Ischemia/Reperfusion Rats." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2020, pp. 6980398, (2020) (PubMed).
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A20-Binding Inhibitor of NF-κB 1 Ameliorates Neuroinflammation and Mediates Antineuroinflammatory Effect of Electroacupuncture in Cerebral Ischemia/Reperfusion Rats." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2020, pp. 6980398, (2020) (PubMed).
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- Antigène
- TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))
- Autre désignation
- TNIP1 (TNIP1 Produits)
- Sujet
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Synonyms: ABIN 1, ABIN-1, abin1, HIV-1 Nef interacting protein Nip40-1, TNFAIP3 interacting protein 1, HIV-1 Nef interacting protein, HIV-1 Nef-interacting protein, hVAN, KIAA0113, NAF 1, NAF-1, NAF1, Nef-associated factor 1, Nef-associated factor 1 SNP, Nip 40-1, Nip40-1, TNFAIP3 interacting protein 1, TNFAIP3-interacting protein 1, TNIP 1, TNIP-1, Tnip1, TNIP1_HUMAN, VAN, Virion associated nuclear shuttling protein, Virion-associated nuclear shuttling protein.
Background: Abin-1 is a 636 amino acid protein that localizes to both the nucleus and the cytoplasm and is shuttled between the two intercellular regions in a CRM1-dependent manner. Expressed ubiquitously with highest expression in spleen and skeletal muscle, Abin-1 interacts with A20 and, via this interaction, interferes with TRAF2-mediated transactivation signals and effectively inhibits TNF-induced NF_B expression. Additionally, Abin-1 can be incorporated into HIV-1 virions and, if overexpressed, can inhibit viral replication. Abin-1 may also play an important role in the regulation of nuclear import and export activities. Multiple isoforms of Abin-1 exist due to alternative splicing events.
- Pathways
- Activation of Innate immune Response
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