O3FAR1 anticorps (AA 21-120)

N° du produit ABIN1387736

Détail du produit anti-O3FAR1 anticorps

Antigène: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Épitope: AA 21-120

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp O3FAR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human G protein coupled receptor 120

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-O3FAR1 (ABIN1387736)

Meng, Yuan, Zhang, Zhang, Fu, Zhu, Shu, Wang, Gao, Xi, Sun, Zhang, Jiang, Wang: "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." dans: Biochemical and biophysical research communications, Vol. 491, Issue 1, pp. 192-197, (2017) (PubMed).

Détails sur O3FAR1

Antigène: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Autre désignation: GPR120 (O3FAR1 Produits)

Synonymes: anticorps BMIQ10, anticorps GPR120, anticorps GPR129, anticorps GT01, anticorps O3FAR1, anticorps PGR4, anticorps AI552415, anticorps Gpr120, anticorps Gpr129, anticorps KPG_013, anticorps O3far1, anticorps Pgr4, anticorps free fatty acid receptor 4, anticorps phosphodiesterase 6C, anticorps FFAR4, anticorps Ffar4, anticorps PDE6C

Sujet:

Synonyms: G protein coupled receptor 120, GPCR GPR120, G protein coupled receptor 129, G protein coupled receptor GT01, G protein coupled receptor PGR 4, G protein coupled receptor PGR4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, GPR 120, GPR 129, GPR120, GPR129, GT01, HGNC:19345, MGC119984, O3FA1_HUMAN, O3FAR1, Omega-3 fatty acid receptor 1, PGR 4, PGR4, GPCR120.

Background: GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.

ID gène: 338557

UniProt: Q5NUL3

Pathways: Hormone Transport