ELL3 anticorps (AA 51-158)

N° du produit ABIN1387782

Détail du produit anti-ELL3 anticorps

Antigène: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Épitope: AA 51-158

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELL3 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ELL3

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ELL3

Antigène: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Autre désignation: ELL3 (ELL3 Produits)

Synonymes: anticorps DKFZp469F0639, anticorps A930015D22Rik, anticorps elongation factor for RNA polymerase II 3, anticorps elongation factor RNA polymerase II-like 3 L homeolog, anticorps elongation factor RNA polymerase II-like 3, anticorps ELL3, anticorps ell3.L, anticorps Ell3

Sujet:

Synonyms: B cell translocation gene 2, BTG family member 2, Btg2, BTG2_HUMAN, Nerve growth factor inducible anti prolerative, NGF inducible anti prolerative protein PC3, NGF-inducible anti-prolerative protein PC3, PC3, Pheochromacytoma cell 3, Protein BTG2, TIS21.

Background: Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.

ID gène: 80237

Pathways: Negative Regulation of intrinsic apoptotic Signaling