FAM126A anticorps (AA 1-100)

N° du produit ABIN1387791

Détail du produit anti-FAM126A anticorps

Antigène: FAM126A (Family with Sequence Similarity 126, Member A (FAM126A))

Épitope: AA 1-100

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM126A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Hyccin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FAM126A

Antigène: FAM126A (Family with Sequence Similarity 126, Member A (FAM126A))

Autre désignation: FAM126A/Hyccin (FAM126A Produits)

Synonymes: anticorps DRCTNNB1A, anticorps HCC, anticorps HLD5, anticorps HYCC1, anticorps AB030242, anticorps Drctnnb1a, anticorps RGD1562906, anticorps zgc:77228, anticorps fam126a, anticorps family with sequence similarity 126 member A, anticorps family with sequence similarity 126, member A, anticorps family with sequence similarity 126 member A S homeolog, anticorps FAM126A, anticorps Fam126a, anticorps fam126a, anticorps fam126a.S

Sujet:

Synonyms: Down regulated by Ctnnb1 a, Down regulated by CTNNB1 protein A, Down-regulated by CTNNB1 protein A, DRCTNNB1A, FAM126A, Family with sequence similarity 126 member A, HCC, HLD5, HYCC1, HYCCI_HUMAN antibody Hyccin, Protein FAM126A.

Background: Hyccin is a 521 amino acid cytoplasmic protein that is widely expressed with highest levels found in heart, brain, placenta, spleen and testis. Belonging to the FAM126 family, hyccin may play a role in the -catenin/Lef signaling pathway. Hyccin is likely involved in the process of myelination of the central and peripheral nervous system. Defects in the gene encoding hyccin are the cause of leukodystrophy hypomyelinating type 5 (HLD5), which is characterized by congenital cataract, progressive neurologic impairment and diffuse myelin deficiency. Individuals affected by HLD5 experience progressive pyramidal and cerebellar dysfunction along with muscle weakness in the lower limbs. Hyccin exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 7.