HAO1 anticorps (AA 261-370)
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- Antigène Voir toutes HAO1 Anticorps
- HAO1 (Hydroxyacid Oxidase (Glycolate Oxidase) 1 (HAO1))
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Épitope
- AA 261-370
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HAO1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat,Dog,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GOX/HAO1
- Isotype
- IgG
- Top Product
- Discover our top product HAO1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- HAO1 (Hydroxyacid Oxidase (Glycolate Oxidase) 1 (HAO1))
- Autre désignation
- HAO1 (HAO1 Produits)
- Synonymes
- anticorps hao1, anticorps GOX, anticorps GOX1, anticorps HAOX1, anticorps Gox1, anticorps XDH1, anticorps Hao-1, anticorps hydroxyacid oxidase 1, anticorps hydroxyacid oxidase (glycolate oxidase) 1, anticorps hydroxyacid oxidase (glycolate oxidase) 1 L homeolog, anticorps hydroxyacid oxidase 1, liver, anticorps CpipJ_CPIJ013711, anticorps THEYE_A0075, anticorps hao1, anticorps HAO1, anticorps hao1.L, anticorps Hao1
- Sujet
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Synonyms: Glycolate oxidase, GOX, GOX1, HAO1, HAOX1, HAOX1_HUMAN, Hydroxyacid oxidase 1, MGC142225, MGC142227, OTTHUMP00000030231, S 2 hydroxy acid oxidase.
Background: GOX is a 370 amino acid protein that is expressed in liver and pancreas. HAO1 is localized to peroxisomes and aids in organic acid metabolism via 2-hydroxyacid oxidase activity. 2-hydroxyacid oxidases, such as HAO1, are enzymes that require a flavin cofactor to oxidize 2-hydroxyacids to 2-ketoacids while reducing oxygen to hydrogen peroxide. HAO1 prefenentially oxidizes the substrate glycolate and also oxidizes other substrates, including 2-hydroxy fatty acids as well as L-?hydroxy acids of moderately short chain lengths. The oxidation of glycolate yields glyoxylate which is utilized for peroxisomal synthesis of glycine. HAO1 is also able to convert glyoxylate to oxalate. HAO1 is thought to play a role in the pathophysiology of hyperoxaluria type 1, which is caused by defects in AGXT, a peroxisomal enzyme, leading to accumulation of glyoxylate. Hyperoxaluria type 1 is characterized by an accumulation of oxalate that is thought to lead to precipitates of calcium oxalate in kidneys which can be fatal.
- Pathways
- Monocarboxylic Acid Catabolic Process
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