MMS19 anticorps (AA 851-950)

N° du produit ABIN1387802

Détail du produit anti-MMS19 anticorps

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Épitope: AA 851-950

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMS19 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MMS 19

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MMS19

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Autre désignation: MMS19 (MMS19 Produits)

Synonymes: anticorps MET18, anticorps MMS19L, anticorps hMMS19, anticorps 2410001K24Rik, anticorps 2610042O15Rik, anticorps AI316855, anticorps C79368, anticorps C86341, anticorps Mms19l, anticorps mms19, anticorps mms19l, anticorps MMS19 homolog, cytosolic iron-sulfur assembly component, anticorps MMS19 (MET18 S. cerevisiae), anticorps MMS19 homolog, cytosolic iron-sulfur assembly component L homeolog, anticorps MMS19, anticorps Mms19, anticorps mms19.L

Sujet:

Synonyms: MET18, MMS19L, hMMS19, MMS19 nucleotide excision repair protein homolog, MET18 homolog, MMS19-like protein, MMS19

Background: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

ID gène: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding