MPL anticorps (AA 401-500)

N° du produit ABIN1387832

Détail du produit anti-MPL anticorps

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Épitope: AA 401-500

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPL est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TPOR

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MPL

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: TPOR (MPL Produits)

Synonymes: anticorps C-MPL, anticorps CD110, anticorps MPLV, anticorps THCYT2, anticorps TPOR, anticorps TPO-R, anticorps c-mpl, anticorps c-mpl-I, anticorps c-mpl-II, anticorps hlb219, anticorps MPL, anticorps mpll, anticorps tpor, anticorps tpor.b, anticorps MPL proto-oncogene, thrombopoietin receptor, anticorps myeloproliferative leukemia virus oncogene, anticorps MPL, anticorps Mpl, anticorps mpl

Sujet:

Synonyms: C MPL, C-MPL, CMPL, CD110, CD 110, MPL, MPLV, Myeloprolerative leukemia protein, Myeloprolerative leukemia virus oncogene, Proto-oncogene c-Mpl, THCYT2, Thrombopoietin receptor, TPO R, TPO-R, TPOR, TPOR_HUMAN.

Background: Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells. TPO exerts its biological effects through the TPO receptor, c-Mpl. c-Mpl is a member of the cytokine receptor superfamily. Expression of c-Mpl is restricted to hematopoietic tissues and cells, such as bone marrow, spleen, fetal liver and CD34+ cells. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2, which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome.

Pathways: Signalistation JAK/STAT