CCT2 anticorps (AA 131-230)

N° du produit ABIN1387920

Détail du produit anti-CCT2 anticorps

Antigène: CCT2 (Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2))

Épitope: AA 131-230

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCT2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CCT2/TCP1 beta

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CCT2

Antigène: CCT2 (Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2))

Autre désignation: CCT2/TCP1 beta (CCT2 Produits)

Sujet:

Synonyms: CCT 2, CCT beta, CCT-beta, CCT-2, CCTB, Chaperonin containing t complex polypeptide 1 beta subunit, Chaperonin containing t complex polypeptide 1 subunit 2, Chaperonin containing TCP1 subunit 2, Chaperonin containing TCP1 subunit 2 beta, CTP:phosphocholine cytidylyltransferase 2, MGC142074, MGC142076, MGC94480, PRO1633, T complex protein 1 beta subunit, T complex protein 1 subunit beta, T-complex protein 1 subunit beta, TCP 1 beta, TCP-1-beta, TCPB_HUMAN, 99D8.1.

Background: CCT2 is one of eight largely unrelated subunit proteins found in a protein chaperone complex known as the chaperonin-containing TCP-1 (CCT) or TRiC complex. The CCT complex is an abundanct cytoslic component that is credited with helping newly synthesized polypeptides adopt the correct conformation (1). Proteins that fold and assemble with the help of CCT include the cytoskeletal proteins actin and tubulin as well as up to 15 % of newly synthesized eukaryotic proteins (2). CCT2 is the _-subunit of the chaperone complex and is one of several CCT proteins that exhibit increased expression in response to stress. This implies that the CCT complex helps cells recover from protein damage by assisting in protein folding and assembly (3). CCT subunit levels also change throughout the cell cycle, with lower proteins levels (and reduced chaperone activity) found during induced cell cycle arrest during at M phase (4). Each CCT subunit is thought to perform a specific function during protein folding and assembly (5), CCT2 exhibits both actin and tubulin binding activities (6,3) but the exact molecular function on this subunit remains uncertain.