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AAV VP1 anticorps (AbBy Fluor® 350)

AAV VP1 Reactivité: Adeno-Associated Virus (AAV) IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 350
N° du produit ABIN1388673
  • Antigène Tous les produits AAV VP1
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    Reactivité
    Adeno-Associated Virus (AAV)
    Hôte
    • 13
    Lapin
    Clonalité
    • 13
    Polyclonal
    Conjugué
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AAV VP1 est conjugé à/à la AbBy Fluor® 350
    Application
    • 11
    • 11
    • 3
    • 3
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Specificité
    This antibody will recognize many AAV strains, including AAV5, AAV4, AAV3B, AAV9, and AAV13
     Réactivité croisée
    Virus
    Réactivité croisée (Details)
    AAV5
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1
    Isotype
    IgG
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    Autre désignation
    Adeno-Associated Virus Capsid Protein VP1 (AAV VP1 Produits)
    Classe de substances
    Viral Protein
    Sujet

    Synonyms: capsid protein Adeno-associated 5 virus, capsid protein [Adeno-associated virus - 5], capsid protein AAV5, Parvovirus coat protein VP1, capsid protein.

    Background: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus

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