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GAN anticorps (AA 351-450) (AbBy Fluor® 647)

GAN Reactivité: Rat IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN1388826
  • Antigène Voir toutes GAN Anticorps
    GAN (Gigaxonin (GAN))
    Épitope
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-450
    Reactivité
    • 19
    • 14
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 24
    • 4
    Lapin
    Clonalité
    • 25
    • 3
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GAN est conjugé à/à la AbBy Fluor® 647
    Application
    • 12
    • 12
    • 9
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Gigaxonin
    Isotype
    IgG
    Top Product
    Discover our top product GAN Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GAN (Gigaxonin (GAN))
    Autre désignation
    Gigaxonin (GAN Produits)
    Synonymes
    anticorps MGC81691, anticorps GAN, anticorps A330045G18, anticorps gigaxonin, anticorps GAN1, anticorps KLHL16, anticorps gigaxonin L homeolog, anticorps gigaxonin, anticorps giant axonal neuropathy, anticorps gan.L, anticorps gan, anticorps GAN, anticorps Gan
    Sujet

    Synonyms: FLJ38059, GAN, GAN1, Kelch-like protein 16, giant axonal neuropathy, KLHL16, GAN_HUMAN.

    Background: Gigaxonin, also refered to as giant axonal neuropathy, GAN1, or KLHL16, controls protein degradation and is essential for neuronal function and survival. Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, playing a large role in neurofilament architecture. The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), and tags it for degredation. Overexpression of MAP1B may lead to neuronal cell death, whereas a reduction of MAP1B significantly improves the survival rate of neurons. Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, including accumulated intermediate filaments.

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