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Bestrophin 2 anticorps (AA 101-200) (AbBy Fluor® 555)

BEST2 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN1388921
  • Antigène Voir toutes Bestrophin 2 (BEST2) Anticorps
    Bestrophin 2 (BEST2)
    Épitope
    • 14
    • 8
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 101-200
    Reactivité
    • 36
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 37
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 12
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Bestrophin 2 est conjugé à/à la AbBy Fluor® 555
    Application
    • 21
    • 21
    • 18
    • 12
    • 12
    • 8
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Bestrophin 2
    Isotype
    IgG
    Top Product
    Discover our top product BEST2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Bestrophin 2 (BEST2)
    Autre désignation
    Bestrophin 2 (BEST2 Produits)
    Synonymes
    anticorps VMD2L1, anticorps CG10173, anticorps Dmel\\CG10173, anticorps dbest2, anticorps Vmd2l1, anticorps best2, anticorps vmd2l1, anticorps MGC53680, anticorps MGC132361, anticorps Best2, anticorps GB16861, anticorps si:dkey-121b10.4, anticorps MGC75942, anticorps best2-a, anticorps best2-b, anticorps variant 2, anticorps bestrophin 2, anticorps Bestrophin 2, anticorps bestrophin 2 L homeolog, anticorps uncharacterized LOC408898, anticorps bestrophin 2 S homeolog, anticorps BEST2, anticorps Best2, anticorps best2.L, anticorps LOC408898, anticorps best2, anticorps best2.S
    Sujet

    Synonyms: BEST 2, Best disease Bestrophin, BEST2, Bestrophin2, FLJ20132, Vitellorm macular dystrophy 2 homolog, Vitellorm macular dystrophy 2 like 1, Vitellorm macular dystrophy 2 like protein 1, Vitellorm macular dystrophy, VMD2, VMD2 like gene 1, VMD2L1, BEST2_HUMAN.

    Background: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.

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