CYTIP anticorps (AA 1-100) (FITC)
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- Antigène Voir toutes CYTIP Anticorps
- CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
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Épitope
- AA 1-100
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CYTIP est conjugé à/à la FITC
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
- Isotype
- IgG
- Top Product
- Discover our top product CYTIP Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
- Autre désignation
- PSCDBP/CYTIP (CYTIP Produits)
- Synonymes
- anticorps B3-1, anticorps CASP, anticorps CYBR, anticorps CYTHIP, anticorps HE, anticorps PSCDBP, anticorps A130053M09Rik, anticorps AI462064, anticorps C80816, anticorps Cbp, anticorps Cybr, anticorps Pscdbp, anticorps cytohesin 1 interacting protein, anticorps CYTIP, anticorps Cytip, anticorps cytip
- Sujet
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Synonyms: B31, CASP, Cbp HE, CYBR, CYTHIP, Cytip, CYTIP_HUMAN, Cytohesin binder and regulator, Cytohesin-associated scaffolding protein, Cytohesin-binding protein HE, Cytohesin-interacting protein, HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein, Pleckstrin homology Sec7 and coiled-coil domains-binding protein.
Background: CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.
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