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Neurexin 2 (NRXN2) (AA 971-1070) anticorps (AbBy Fluor® 647)

NRXN2 Reactivité: Rat IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN1389294
  • Antigène Voir toutes Neurexin 2 (NRXN2) Anticorps
    Neurexin 2 (NRXN2)
    Épitope
    AA 971-1070
    Reactivité
    • 15
    • 1
    Rat
    Hôte
    • 15
    Lapin
    Clonalité
    • 15
    Polyclonal
    Conjugué
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AbBy Fluor® 647
    Application
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NRXN2
    Isotype
    IgG
    Top Product
    Discover our top product NRXN2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Neurexin 2 (NRXN2)
    Autre désignation
    Neurexin 2 (NRXN2 Produits)
    Synonymes
    anticorps neurexin 2, anticorps NRXN2, anticorps Nrxn2
    Sujet

    Synonyms: Neurexin 2, Neurexin-2, Neurexin2, Neurexin II, Neurexin II alpha, NRXN 2, NRXN-2, NRXN2, NRX2A_HUMAN.

    Background: Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.

    UniProt
    Q9P2S2
    Pathways
    Synaptic Membrane
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