GRAF anticorps (AA 1-100) (Biotin)

N° du produit ABIN1390153

Détail du produit anti-GRAF anticorps (Biotin)

Antigène: GRAF (ARHGAP26) (rho GTPase Activating Protein 26 (ARHGAP26))

Épitope: AA 1-100

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRAF est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GRAF1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GRAF

Antigène: GRAF (ARHGAP26) (rho GTPase Activating Protein 26 (ARHGAP26))

Autre désignation: GRAF1 (ARHGAP26 Produits)

Sujet:

Synonyms: arhgap 26, ARHGAP26, FLJ42530, GRAF, GRAF1, GTPase regulator associated with focal adhesion kinase, GTPase regulator associated with focal adhesion kinase pp125FAK, KIAA0621, oligophrenin 1 like protein, Oligophrenin-1-like protein, oligophrenin1like protein, OPHN1L, OPHN1L1, RHG26_HUMAN, Rho GTPase activating protein 26, Rho GTPase activating protein26, Rho GTPase-activating protein 26, Rho-type GTPase-activating protein 26.

Background: Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.