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Myosin VI anticorps (AA 1101-1294) (Biotin)

MYO6 Reactivité: Souris, Rat ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1390243
  • Antigène Voir toutes Myosin VI (MYO6) Anticorps
    Myosin VI (MYO6)
    Épitope
    • 14
    • 8
    • 8
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    AA 1101-1294
    Reactivité
    • 30
    • 25
    • 25
    • 1
    • 1
    Souris, Rat
    Hôte
    • 43
    • 1
    Lapin
    Clonalité
    • 43
    • 1
    Polyclonal
    Conjugué
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Myosin VI est conjugé à/à la Biotin
    Application
    • 23
    • 19
    • 17
    • 13
    • 13
    • 13
    • 7
    • 6
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Myosin VI
    Isotype
    IgG
    Top Product
    Discover our top product MYO6 Anticorps primaire
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    Myosin VI (MYO6)
    Autre désignation
    MYO6/Myosin VI (MYO6 Produits)
    Synonymes
    anticorps 95F, anticorps 95F MHC, anticorps CG5695, anticorps Dm 95F, anticorps Dm95F, anticorps Dmel\\CG5695, anticorps Dro95F, anticorps JAG, anticorps Jaguar, anticorps Jar, anticorps M6, anticorps MHC95F, anticorps MYOVI, anticorps Mhc95F, anticorps MyoVI, anticorps Myosin VI, anticorps jag, anticorps ms(3)06746, anticorps myosins VI, anticorps DFNA22, anticorps DFNB37, anticorps BC029719, anticorps Tlc, anticorps sv, anticorps RGD1560646, anticorps CMY6, anticorps jaguar, anticorps myosin VI, anticorps jar, anticorps LOC373230, anticorps MYO6, anticorps myo6, anticorps Myo6
    Sujet

    Synonyms: Deafness autosomal recessive 37, DFNA 22, DFNA22, DFNB 37, DFNB37, KIAA0389, MYO 6, Myo6, MYO6_HUMAN, Myosin 6, Myosin VI, Myosin-VI, Myosin6, MyosinVI, Unconventional myosin-6.

    Background: Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, is the only Myosin motor that binds to the pointed end of Actin. This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, unlike that of other characterized Myosins. It associates with Clathrin-coated vesicles and disabled 2, indicating a role for Myosin VI in endocytosis. Mouse Myosin VI is expressed within the sensory hair cells of the cochlea. Human Myosin VI is mapped to the centromeric region of chromosome 6, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, where the Snell?s Waltzer mutation is located. The behavioral effects of the mouse Snell?s Waltzer mutation are lack of responsiveness to sound, hyperactivity, head tossing and circling, due to the disorganization and fusing of stereocilia bundles within the inner ear. Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans. Human Myosin VI is expressed in fetal cochlea and brain, as well as in adult brain.

    Pathways
    Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization
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