HSD17B4 anticorps (AA 521-620) (AbBy Fluor® 488)

N° du produit ABIN1390426

Détail du produit anti-HSD17B4 anticorps (AbBy Fluor® 488)

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Épitope: AA 521-620

Reactivité: Souris, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B4 est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Mouton, Poisson zèbre (Danio rerio)

Homologie: Human,Rat,Cow,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HSD17B4

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Autre désignation: HSD17B4 (HSD17B4 Produits)

Synonymes: anticorps zgc:55545, anticorps zgc:77300, anticorps CG3415, anticorps DmMFE-2, anticorps Dmel\\CG3415, anticorps MFE-2, anticorps DBP, anticorps MPF-2, anticorps PRLTS1, anticorps SDR8C1, anticorps 17-beta-HSD, anticorps 17[b]-HSD, anticorps 4, anticorps MFP2, anticorps Mfp-2, anticorps perMFE-2, anticorps hydroxysteroid (17-beta) dehydrogenase 4, anticorps hydroxysteroid 17-beta dehydrogenase 4, anticorps peroxisomal Multifunctional enzyme type 2, anticorps hsd17b4, anticorps HSD17B4, anticorps Mfe2, anticorps Hsd17b4

Sujet:

Synonyms: hydroxysteroid 17-beta dehydrogenase 4, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, 17 beta HSD 4, 17 beta HSD IV, 17 beta hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, 17-beta-hydroxysteroid dehydrogenase 4, 17beta estradiol dehydrogenase type IV, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody 3-alpha, 7-alpha, Beta hydroxyacyl dehydrogenase, Beta keto reductase, D 3 hydroxyacyl CoA dehydratase, D bunctional protein, D bunctional protein peroxisomal, D-bunctional protein, DBP, DHB4_HUMAN, EDH17B4, Enoyl-CoA hydratase 2, Hsd17b4, MFE 2, MFE-2, MPF-2, Multunctional protein 2, Peroxisomal multunctional enzyme type 2, Peroxisomal multunctional protein 2, SDR8C1, Short chain dehydrogenase/reductase family 8C member 1.

Background: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.

Pathways: Monocarboxylic Acid Catabolic Process