Hippocalcin anticorps (AA 101-193) (Biotin)

N° du produit ABIN1390741

Détail du produit anti-Hippocalcin anticorps (Biotin)

Antigène: Hippocalcin (HPCA)

Épitope: AA 101-193

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Hippocalcin est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Hippocalcin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Hippocalcin

Antigène: Hippocalcin (HPCA)

Autre désignation: Hippocalcin (HPCA Produits)

Synonymes: anticorps zgc:73126, anticorps MGC80408, anticorps MGC84992, anticorps bdr2, anticorps BDR2, anticorps hippocalcin, anticorps hippocalcin S homeolog, anticorps hpca, anticorps hpca.S, anticorps HPCA, anticorps Hpca

Sujet:

Synonyms: BDR 2, BDR2, Calcium binding protein BDR 2, Calcium binding protein BDR2, Calcium-binding protein BDR-2, Hpca, HPCA_HUMAN, Neuron specic calcium binding protein hippocalcin, Neuron specic calcium-binding protein hippocalcin, Neuron-specic calcium-binding protein hippocalcin,P23K.

Background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.