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Nogo B Receptor anticorps (AA 167-210) (AbBy Fluor® 350)

NUS1 Reactivité: Humain WB, IF (p), IF (cc) Hôte: Lapin Polyclonal AbBy Fluor® 350
N° du produit ABIN1391445
  • Antigène Voir toutes Nogo B Receptor (NUS1) Anticorps
    Nogo B Receptor (NUS1)
    Épitope
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 167-210
    Reactivité
    • 20
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 19
    • 1
    Lapin
    Clonalité
    • 19
    • 1
    Polyclonal
    Conjugué
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Nogo B Receptor est conjugé à/à la AbBy Fluor® 350
    Application
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor
    Isotype
    IgG
    Top Product
    Discover our top product NUS1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Nogo B Receptor (NUS1)
    Autre désignation
    NGBR/Nogo B receptor (NUS1 Produits)
    Synonymes
    anticorps C6orf68, anticorps MGC:7199, anticorps NgBR, anticorps TANGO14, anticorps 1600027K07Rik, anticorps AU019165, anticorps AW538011, anticorps BC003223, anticorps D10Ertd438e, anticorps NUS1 dehydrodolichyl diphosphate synthase subunit, anticorps NUS1, anticorps Nus1
    Sujet

    Synonyms: C6orf68, NGBR, nuclear undecaprenyl pyrophosphate synthase 1 homolog, NUS1, NGBR_HUMAN, Dehydrodolichyl diphosphate synthase complex subunit NUS1, Cis-prenyltransferase subunit NgBR, Nogo-B receptor.

    Background: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.

    ID gène
    116150
    UniProt
    Q96E22
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