FEZF1 anticorps (AA 199-280) (AbBy Fluor® 488)
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- Antigène Voir toutes FEZF1 Anticorps
- FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
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Épitope
- AA 199-280
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FEZF1 est conjugé à/à la AbBy Fluor® 488
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ZNF312B
- Isotype
- IgG
- Top Product
- Discover our top product FEZF1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
- Autre désignation
- ZNF312B/FEZF1 (FEZF1 Produits)
- Synonymes
- anticorps RGD1560480, anticorps fezf, anticorps znf312b, anticorps MGC145310, anticorps FEZ, anticorps ZNF312B, anticorps 3110069A13Rik, anticorps Fez, anticorps Zfp312-like, anticorps fez-like, anticorps fez, anticorps fezf2, anticorps wu:fc29c05, anticorps wu:fc89h05, anticorps zgc:153730, anticorps Fez family zinc finger 1, anticorps FEZ family zinc finger 1, anticorps Fez family zinc finger protein 1, anticorps FEZ family zinc finger 1 S homeolog, anticorps Fezf1, anticorps FEZF1, anticorps fezf1, anticorps Tsp_12536a, anticorps Tsp_12536, anticorps fezf1.S
- Sujet
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Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.
Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.
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