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Tubby Protein Homolog 1 (Tub-1) (AA 241-305) anticorps (FITC)

Tub-1 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal FITC
N° du produit ABIN1391852
  • Antigène Voir toutes Tubby Protein Homolog 1 (Tub-1) Anticorps
    Tubby Protein Homolog 1 (Tub-1)
    Épitope
    AA 241-305
    Reactivité
    Humain
    Hôte
    • 14
    Lapin
    Clonalité
    • 14
    Polyclonal
    Conjugué
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    FITC
    Application
    • 14
    • 12
    • 12
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human TUB 1
    Isotype
    IgG
    Top Product
    Discover our top product Tub-1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Tubby Protein Homolog 1 (Tub-1)
    Autre désignation
    TUB 1 (Tub-1 Produits)
    Synonymes
    anticorps Tubby protein homolog 1, anticorps tub-1
    Sujet

    Synonyms: F10B5.4, rd5, TUB 1, TUB, TUB_HUMAN, Tubby homologue, Tubby protein homolog 1, Tubby protein homolog.

    Background: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G_ transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

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