APBA2 anticorps (AA 351-450) (AbBy Fluor® 488)
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- Antigène Voir toutes APBA2 Anticorps
- APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))
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Épitope
- AA 351-450
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp APBA2 est conjugé à/à la AbBy Fluor® 488
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Sheep,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human APBA2
- Isotype
- IgG
- Top Product
- Discover our top product APBA2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))
- Autre désignation
- APBA2 (APBA2 Produits)
- Synonymes
- anticorps MGC83599, anticorps D15S1518E, anticorps HsT16821, anticorps LIN-10, anticorps MGC:14091, anticorps MINT2, anticorps X11-BETA, anticorps X11L, anticorps X11-like, anticorps XllL, anticorps mXllL, anticorps Mint2, anticorps amyloid beta precursor protein binding family A member 2, anticorps amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog, anticorps amyloid beta (A4) precursor protein-binding, family A, member 2, anticorps APBA2, anticorps apba2.L, anticorps Apba2
- Sujet
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Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, APBA2, APBA2_HUMAN, D15S1518E, HsT16821, LIN 10, Mint 2, Mint-2, Neuron-specic X11L protein, Neuronal Munc18-1-interacting protein 2, Phosphotyrosine binding/interacting domain PTB bearing protein, X11 beta, X11l.
Background: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer?s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the -Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).
- Pathways
- Synaptic Vesicle Exocytosis
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