IFT57 anticorps (AA 331-429) (AbBy Fluor® 488)
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- Antigène Voir toutes IFT57 Anticorps
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
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Épitope
- AA 331-429
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IFT57 est conjugé à/à la AbBy Fluor® 488
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human HIPPI
- Isotype
- IgG
- Top Product
- Discover our top product IFT57 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
- Autre désignation
- HIPPI (IFT57 Produits)
- Synonymes
- anticorps Esrrbl1, anticorps 4833420A15Rik, anticorps Hippi, anticorps MHS4R2, anticorps ESRRBL1, anticorps HIPPI, anticorps intraflagellar transport 57, anticorps intraflagellar transport 57 S homeolog, anticorps Ift57, anticorps IFT57, anticorps ift57.S
- Sujet
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Synonyms: Dermal papilla derived protein 8, Dermal papilla-derived protein 8, DERP 8, DERP8, Esrrbl 1, Esrrbl1, ESRRBL1 protein, Estrogen related receptor beta like 1, Estrogen related receptor beta like protein 1, Estrogen-related receptor beta like 1, Estrogen-related receptor beta-like protein 1, FLJ10147, Hip1 Interacting Protein, HIP1 interacting protein HIPPI, Hip1 protein interactor, HIP1-interacting protein, HIPPI, Huntingtin interacting protein 1 interacting protein, Huntingtin interacting protein 1 protein interactor, Huntingtin-interacting protein-1 protein interactor, T 57, t57, T57_HUMAN, Intraflagellar transport 57 homolog Chlamydomonas, Intraflagellar transport 57 homolog, Intraflagellar transport protein 57 homolog, MHS4R2, Vestrogen related receptor beta like 1, Vestrogen-related receptor beta like 1, CDNA FLJ10147 fis clone HEMBA1003369.
Background: Programmed neuronal cell death is a feature of neurodegenerative disorders such as Alzheimer's and Huntington's disease, which occur later in human life. Huntington?s disease at the molecular and cell level is characterized by polyglutamine expansion of the protein huntingtin (Htt) that leads to apoptotis-mediated neurodegenerative loss of medium spiny neurons throughout the striatum. Polyglutamine expansion reduces the level of association between Hip-1 and Htt, thereby increasing levels of free Hip-1 that then can be the candidate protein Hippi (Hip-1 protein interactor). The Hippi-Hip-1 heterodimer is a pro-apoptotic complex that recruits procaspase-8 and initiates caspase-8 activation, which may contribute to the neuronal cell death observed in individuals diagnosed with Huntington?s disease. The human hippi gene maps to chromosome 3q13.13 and encodes a 429 amino acid protein.
- Pathways
- Signalisation Hedgehog, Positive Regulation of Endopeptidase Activity
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