ALS2 anticorps (AA 1384-1440) (AbBy Fluor® 350)
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- Antigène Voir toutes ALS2 Anticorps
- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
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Épitope
- AA 1384-1440
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ALS2 est conjugé à/à la AbBy Fluor® 350
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ALS2
- Isotype
- IgG
- Top Product
- Discover our top product ALS2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
- Autre désignation
- ALS2/Alsin (ALS2 Produits)
- Synonymes
- anticorps als2, anticorps si:dkey-33m14.1, anticorps ALS2CR6, anticorps ALSJ, anticorps IAHSP, anticorps PLSJ, anticorps 3222402C23Rik, anticorps 9430073A21Rik, anticorps Als2cr6, anticorps Alsin, anticorps mKIAA1563, anticorps amyotrophic lateral sclerosis 2a (juvenile), anticorps alsin, anticorps ALS2, alsin Rho guanine nucleotide exchange factor, anticorps amyotrophic lateral sclerosis 2 (juvenile), anticorps als2a, anticorps CpipJ_CPIJ008258, anticorps CpipJ_CPIJ008260, anticorps ALS2, anticorps Als2
- Sujet
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Synonyms: ALS 2, ALS2, ALS2_HUMAN, ALS2CR6, Alsin, ALSJ, Amyotrophic lateral sclerosis 2 juvenile, Amyotrophic lateral sclerosis 2 juvenile chromosome region candidate 6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, Amyotrophic lateral sclerosis protein 2, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ.
Background: Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP), and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein that is associated with small, punctate membrane structures. Therefore, Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity.
- Pathways
- Skeletal Muscle Fiber Development
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